摘要：

Defects in apoptotic regulation contribute to many disorders. Insufficient leads to neoplastic and and . Enhanced is a cause of and complicates processes of . Genetic changes involving oncogenes and suppressor genes contribute to the unregulated expansion of malignant cells. While some of these changes result in increased proliferation, others contribute to increasing cell numbers by inhibiting . Because cytotoxic drugs or irradiation result in by , the genetic changes underlying often reduce the ability of these agents to destroy malignant cells. Knowledge of the molecular mechanisms of provides insight into the causes of where aberrant regulation occurs and provides new approaches to the treatment of diseases.

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