The use of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia.
摘要：
Arsenic trioxide (As2O3) has been shown to be even more effective than all-trans retinoid (ATRA) in the treatment of acute promyelocytic leukemia (APL). The combination of induction of apoptosis, induction of differentiation and inhibiting the proliferation, and killing of APL cells could be the main cellular mechanisms of As2O3 in APL treatment. As2O3 may affect APL cells by disturbing the activities of some important intracorporal enzymes, regulating the related gene expression and arresting the progression of cell cycle.
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关键词：
Humans Leukemia, Promyelocytic, Acute Oxides Arsenicals Antineoplastic Agents Treatment Outcome Remission Induction Tissue Distribution Dose-Response Relationship, Drug Cell Division
DOI：
doi:10.1007/BF02781736
被引量：
年份：
1999
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