摘要：

Casein Kinase I (CKI) isonservedomponentfhe Wntignaling pathway, whichegulatesellate determination inetazoans. Wehowhat post-embryonicsymmetric divisionndatepecificationf. elegans epidermaltemellsreontrolledy non-canonical Wnt/beta-cateninignaling pathway, involvingheeta-catenins WRM-1ndYS-1,ndhat. elegans kin-19/CKIalphaunctions inhis pathway.urthermore, weindhat kin-19 ishenlyemberfhe Wntsymmetry pathwayhatunctions with,r in parallelo,heeterochronicemporal patterning pathwayoontrol withdrawalromelf-renewalndubsequenterminal differentiationf epidermaltemells. Wehowhat, except inheasef kin-19,he Wntsymmetry pathwayndheeterochronic pathwayunctioneparatelynd in paralleloontrol differentspectsf epidermaltemellatepecification.owever, givenheunctionf kin-19/CKIalpha inoth pathways,ndhatKI, Wntignaling pathwayndeterochronic pathway genesre widelyonserved innimals,urindingsuggesthatKIalphaayunctionsegulatoryubhrough whichsymmetric divisionnderminal differentiationreoordinated indulttemellsf vertebrates.

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