Rhodium-catalyzed enantioselective diboration of simple alkenes.

来自 ACS

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摘要：

Enantioselective catalytic reactions that operate directly on inexpensive unactivated alkenes are extraordinarily useful for the preparation of chiral organic building blocks and new materials. While a number of such processes have been developed, our ability to meet the intensifying demand for inexpensive stereochemically complex materials will require a significant expansion of practical catalytic asymmetric reaction methodology. In this regard, the rhodium-catalyzed enantioselective diboration reaction has been developed in order to address a number of extant problems in catalytic alkene transformation simultaneously. This process provides an enantiomerically enriched reactive dimetalated intermediate which can be converted to a variety of difunctional reaction products.

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关键词：

diastereoselective syntheses, enantioselective syntheses (incl. cis/trans‐isomerism hydroboration, boration alcohols (acyclic compounds alcohols (benzene compounds alcohols (naphthalene compounds indan derivatives

DOI：

10.1002/chin.200345027

被引量：

380

年份：

2003