摘要：

N-substituted amino acids are described which when coupled with 1,2,3, 4-tetrahydroisoquinolines result in substituted acyl derivatives of 1,2,3, 4-tetrahydroisoquinoline-3-carboxylic acids as anti- hypertensive agents. The novel intermediates are in turn prepared by reacting an amino acid such as alanine with 2-bromo-4-phenyl butanoic acid or an ester thereof.

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