The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

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181

摘要:

A series of rat neuro/glioblastomas all contain the same transforming gene ( neu ) which induces synthesis of a tumour antigen of relative molecular mass ( M r ) 185,000 (p185). The neu oncogene bears homology to erb - B and the tumour antigen, p185, is serologically related to the epidermal growth factor (EGF) receptor. The two proteins, EGF receptor and p185 appear to be distinct, as they coexist in nontransformed Rat-1 cells.

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DOI:

10.1038/312513a0

被引量:

3418

年份:

1984

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2010
被引量:182

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