Asymmetric synthesis of butenolide and butyrolactone derivatives
摘要：
2-Trimethylsiloxyfuran and 4-methoxy-2-trimethylsiloxyfuran, which are readily prepared from butenolide and methyl tetronate respectively, have been reacted with a series of homochiral ortho-esters and oxazolidine derivatives in the presence of Lewis acids to afford homochiral 2(5H)-furanone derivatives. The structures of these products have been determined using nmr spectroscopy and, where possible, by X-ray analysis. Preliminary experiments have been carried out involving conjugate addition to these unsaturated lactones, demonstrating their potential as substrates for natural product synthesis.
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关键词：
BETA-KETO-GAMMA-ALKOXYSULFOXIDES SYN AND ANTI-1,2-DIOLS BETA-KETOSULFOXIDES REDUCTION 2-DEOXY-D-RIBOSE 2-DEOXY-L-XYLOSE MALIC ACID
DOI：
10.1016/0957-4166(94)80085-5
被引量：
年份：
1994
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