A comparison of RNA with DNA in template-directed synthesis
摘要：
Nonenzymatic template-directed copying of sequences rich in cytidylic acid using 5'-(2-methylimidazol-1-yl phosphates) as substrates is substantially more efficient than the copying of corresponding DNA sequences. However, many sequences cannot be copied, and the prospect of replication in this system is remote, even for . Surprisingly, wobble-pairing leads to much more efficient incorporation of G opposite U on templates than of G opposite T on DNA templates.
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关键词：
Cytidine Monophosphate DNA Directed Molecular Evolution Exobiology RNA Base Pairing Base Sequence DNA Primers Deoxyribonucleotides Evolution, Molecular
DOI：
10.1002/1522-2675(20000809)83:83.0.CO;2-P
被引量：
年份：
2000
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