Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis

来自 EBSCO

阅读量：

作者：

M López，R Nogueiras，M Tena-Sempere，C Diéguez

展开

摘要：

The secretion of growth hormone (GH) is regulated through a complex neuroendocrine control system that includes two major hypothalamic regulators, namely GH-releasing hormone (GHRH) and somatostatin (SST) that stimulate and inhibit, respectively, GH release. Classical experiments involving damage and electrical stimulation suggested that the lateral hypothalamic area (LHA) modulated the somatotropic axis, but the responsible molecular mechanisms were unclear. Evidence obtained during the last decade has demonstrated that orexins/hypocretins, a family of peptides expressed in the LHA controlling feeding and sleep, play an important regulatory role on GH, by inhibiting its secretion modulating GHRH and SST neurones. Considering that GH release is closely linked to the sleepwake cycle and feeding state, understanding orexin/hypocretin physiology could open new therapeutic possibilities in the treatment of sleep, energy homeostasis and GH-related pathologies, such as GH deficiency.

展开

关键词：

growth hormone growth hormone-releasing hormone hypothalamus orexins/hypocretins pituitary somatostatin

DOI：

10.1111/j.1748-1716.2009.02042.x

被引量：

年份：

2010