摘要：

Interactions between cells and extracellular environment are mediated through specific cell adhesion sites. These structures are responsible for transmitting environmental signals, which affect essentially all aspects of a cell's life, including proliferation, differentiation and death. The morphology, organization and type of signaling transmitted through these adhesions depend on the chemical identity, geometry and the physical properties of the substrate. Here we outline the cell adhesions organized by fibroblasts on natural two- and within three-dimensional substrates, the signaling associated with these structures and discuss the possible use of this knowledge in assessment of surface biocompatibility of new materials, prepared for regenerative medicine.

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