Rtr1 Is a Dual Specificity Phosphatase That Dephosphorylates Tyr1 and Ser5 on the RNA Polymerase II CTD
摘要:
Rtr1 is a new phosphatase unrelated structurally to known such enzymes.Rtr1's N-terminal domain represents a novel fold for phosphatase function.Disruption of in vitro activity displays gene deletion phenotypes in vivo.The C-terminal region of Rtr1 inhibits phosphatase activity.Rtr1 selectively dephosphorylates both Tyr1 and Ser5 on the PolII CTD.
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DOI:
10.1016/j.jmb.2014.06.010
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年份:
2014































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