Cyclic diarylheptanoids as Na + -glucose cotransporter (SGLT) inhibitors from Acer nikoense
摘要：
Two cyclic diarylheptanoids, acerogenins A ( 1) and B ( 2) have been isolated from the bark of Acer nikoense as inhibitors of Na +-glucose cotransporter (SGLT). Acerogenins A ( 1) and B ( 2) inhibited both isoforms, SGLT1 and SGLT2. Structure–activity relationship of acerogenin derivatives on inhibitory activity of SGLT as well as conformational analysis of 1 and 2 on the basis of J-resolved HMBC spectra and X-ray analysis were discussed.
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DOI：
10.1016/j.bmcl.2009.12.036
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年份：
2010
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