Colorectal carcinoma antigens detected by hybridoma antibodies
摘要：
Hybridoma cells which secrete colorectal carcinoma-specific antibodies have been produced and used to study the antigenic structure of these tumor cells. Nineteen antibodies have been studied in detail, and 15 of these are colorectal carcinoma specific. Only two antibodies reactive with carcinoembryonic antigen (CEA) have been discovered and five other antibodies that react with distinct epitopes on the cell surface have been defined. Several antigens with distinct molecular characteristics have been shown to exist by use of hybridoma antibodies. Six hybridoma antibodies have been shown to mediate antibody-dependent cell-mediated cytotoxicity (ADCC) .
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关键词：
Animals Mice, Inbred BALB C Humans Mice Cell Line Hybrid Cells Carcinoma Colonic Neoplasms Carcinoembryonic Antigen Antibodies, Neoplasm
DOI：
10.1007/BF01542654
被引量：
年份：
1979
Springer
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Springer
dx.doi.org
NCBI
Oxford Univ Press
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