Ras proteins: different signals from different locations.
摘要：
Ras signalling has classically been thought to occur exclusively at the inner surface of a relatively uniform plasma membrane. Recent studies have shown that Ras proteins interact dynamically with specific microdomains of the plasma membrane as well as with other internal cell membranes. These different membrane microenvironments modulate Ras signal output and highlight the complex interplay between Ras location and function.
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关键词：
Cell Biology Clathrin-mediated Endocytosis Plasma-membrane Localization Regulated Kinase Activation H-ras K-ras N-ras Saccharomyces-cerevisiae Phosphoinositide 3-kinase Lipid Rafts
DOI：
10.1038/nrm1105
被引量：
年份：
2003
Nature
Springer
Nature
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