Anticancer diarylheptanoid glycosides from the inner bark of Betula papyrifera
摘要：
Phytochemical investigations of the MeOH extract of Betula papyrifera inner bark led to the isolation of ten phenolic compounds of the following types: diarylheptanoid glycosides ( 1– 4), a diarylheptanoid ( 5), a lignan ( 6), flavonoids ( 7– 8) and chavicol glycosides ( 9– 10). Among them, the diarylheptanoid glycoside, ( S)-1,7-bis-(4-hydroxyphenyl)-heptan-3-one-5- O-α- l-arabinofuranosyl-(1 → 6)-β- d-glucopyranoside, papyriferoside A ( 1), was isolated and its structure was determined on the basis of 1D and 2D NMR, HPLC-MS, as well as high resolution mass spectroscopic data. Platyphylloside ( 4) exerted the strongest cytotoxic activity of all isolated compounds with IC 50 values ranging from 10.3 to 13.8 μM.
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关键词：
Betula papyrifera Betulaceae Birch Bark Diarylheptanoid Chavicol Glycoside NMR Cytotoxic Anticancer
DOI：
10.1016/j.phytochem.2007.05.018
被引量：
年份：
2007
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