Regulation of Src Family Kinases in Human Cancers
摘要：
The nonreceptor protein tyrosine kinase Src plays a crucial role in the signal transduction pathways involved in cell division, motility, adhesion, and survival in both normal and cancer cells. Although the Src family kinases (SFKs) are activated in various types of cancers, the exact mechanisms through which they contribute to the progression of individual tumors remain to be defined. The activation of Src in human cancers may occur through a variety of mechanisms that include domain interaction and structural remodeling in response to various activators or upstream kinases and phosphatastes. Because of Src's prominent roles in invasion and tumor progression, epithelial-to-mesenchymal transition, angiogenesis, and the development of metastasis, Src is a promising target for cancer therapy. Several small molecule inhibitors of Src are currently being investigated in clinical trials. In this article, we will summarize the mechanisms regulating Src kinase activity in normal and cancer cells and discuss the status of Src inhibitor development against various types of cancers.
展开
DOI：
10.1155/2011/865819
被引量：
年份：
2011
ACS
Semantic Scholar
(全网免费下载)
dx.doi.org
Europe PMC
(全网免费下载)
NCBI
查看更多
NCBI
(全网免费下载)
Europe PMC
NCBI
Hindawi
(全网免费下载)
Hindawi
(全网免费下载)
OALib
ResearchGate
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
physreports.physiology.org
mendeley.com
doaj.org
embomolmed.embopress.org
mysciencework.com
scienceopen.com
(全网免费下载)
scienceopen.com
pubfacts.com
学术范
core.ac.uk
学术范
(全网免费下载)
deepdyve.com
science-open.com
mailer.oalib.net
onAcademic
Semantic Scholar
(全网免费下载)
Hindawi
(全网免费下载)
Hindawi
(全网免费下载)
Europe PMC
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
学术范
(全网免费下载)
scienceopen.com
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
站内活动
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
