NITROGEN MUSTARD THERAPY: Use of Methyl-Bis(Beta-Chloroethyl)amine Hydrochloride and Tris(Beta-Chloroethyl)amine Hydrochloride for Hodgkin's Disease, Lymphosarcoma, Leukemia and Certain Allied and Miscellaneous Disorders

来自 Semantic Scholar

喜欢 0

阅读量：

161

作者：

LS Goodman，MM Wintrobe

展开

摘要：

In a recent report the historical aspects of the use of β-chloroethyl amines (halogenated alkyl amines, nitrogen mustards) in the treatment of certain diseases of the blood-forming organs were presented and the chemical, pharmacologic, toxicologic and animal experimental aspects of these compounds reviewed.1The interested reader is referred to that report for orientation.The present preliminary communication concerns the clinical use of halogenated alkyl amines in the treatment of lymphosarcoma, Hodgkin's disease, leukemia and a limited number of allied and miscellaneous disorders. In all, 67 patients have been studied. These include 7 patients2treated by L. S. Goodman and Alfred Gilman at the New Haven Hospital; 34 patients treated by M. M. Wintrobe and Margaret T. McLennan at the Salt Lake County General Hospital; 16 patients treated by William Dameshek, Boston, and 10 patients treated by M. J. Goodman, Portland, Ore. The types of diseases treated are shown

展开

关键词：

Leukemia Hodgkin Disease Sarcoma Nitrogen Mustard Compounds Lymphoma, Non-Hodgkin Gas Poisoning

DOI：

10.1001/jama.1946.02870380008004

被引量：

916

年份：

1946