Malaria impairs resistance to Salmonella through heme- and heme oxygenase-dependent dysfunctional granulocyte mobilization.
摘要：
In sub-Saharan Africa, invasive nontyphoid Salmonella (NTS) infection is a common and often fatal complication of Plasmodium falciparum infection. Induction of heme oxygenase-1 (HO-1) mediates tolerance to the cytotoxic effects of heme during malarial hemolysis but might impair resistance to NTS by limiting production of bactericidal reactive oxygen species. We show that co-infection of mice with Plasmodium yoelii 17XNL (Py17XNL) and Salmonella enterica serovar Typhimurium 12023 (Salmonella typhimurium) causes acute, fatal bacteremia with high bacterial load, features reproduced by phenylhydrazine-induced hemolysis or hemin administration. S. typhimurium localized predominantly in granulocytes. Py17XNL, phenylhydrazine and hemin caused premature mobilization of granulocytes from bone marrow with a quantitative defect in the oxidative burst. Inhibition of HO by tin protoporphyrin abrogated the impairment of resistance to S. typhimurium by hemolysis. Thus, a mechanism of tolerance to one infection, malaria, impairs resistance to another, NTS. Furthermore, HO inhibitors may be useful adjunctive therapy for NTS infection in the context of hemolysis.
展开
关键词：
Granulocytes Animals Mice, Inbred C57BL Humans Mice Plasmodium yoelii Salmonella typhimurium Bacteremia Salmonella Infections Malaria
DOI：
10.1038/nm.2601
被引量：
年份：
2012
Nature
Nature
(全网免费下载)
Springer
EBSCO
万方医学
查看更多
Semantic Scholar
(全网免费下载)
dx.doi.org
Europe PMC
NCBI
NCBI
Europe PMC
(全网免费下载)
ResearchGate
ProQuest
ResearchGate
(全网免费下载)
EBSCO
Citeseer
(全网免费下载)
biomedsearch.com
(全网免费下载)
bvsalud.org
pubfacts.com
211.144.68.84:9998
(全网免费下载)
mendeley.com
researchonline.lshtm.ac.uk
(全网免费下载)
cancerimmunolres.aacrjournals.org
readcube.com
perspectivesinmedicine.cshlp.org
deepdyve.com
researchonline.lshtm.ac.uk
(全网免费下载)
学术范
hdl.handle.net
scienceopen.com
onacademic.com
science-open.com
spiral.imperial.ac.uk
embomolmed.embopress.org
eprints.ucl.ac.uk
researchonline.lshtm.ac.uk
spiral.imperial.ac.uk
(全网免费下载)
ukpmc.ac.uk
core.ac.uk
ftp.palgrave-journals.com
core.ac.uk
(全网免费下载)
Europe PMC
www.socolar.com
学术范
(全网免费下载)
Nature
(全网免费下载)
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
biomedsearch.com
(全网免费下载)
spiral.imperial.ac.uk
(全网免费下载)
researchonline.lshtm.ac.uk
(全网免费下载)
core.ac.uk
(全网免费下载)
211.144.68.84:9998
(全网免费下载)
researchonline.lshtm.ac.uk
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
