Activation of the AXL Kinase Causes Resistance to EGFR-Targeted Therapy in Lung Cancer
摘要：
Human non-small cell lung cancers (NSCLCs) with activating mutations in EGFR frequently respond to treatment with EGFR-targeted tyrosine kinase inhibitors (TKIs), such as erlotinib, but responses are not durable, as tumors acquire resistance. Secondary mut
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关键词：
Animals Humans Carcinoma, Non-Small-Cell Lung Lung Neoplasms Quinazolines Receptor, Epidermal Growth Factor Intercellular Signaling Peptides and Proteins Proto-Oncogene Proteins Protein Kinase Inhibitors Xenograft Model Antitumor Assays
DOI：
10.1038/ng.2330
被引量：
年份：
2012
Taylor & Francis
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