Anti-influenza virus effect of aqueous extracts from dandelion
摘要：
p pBackground/p pHuman influenza is a seasonal disease associated with significant morbidity and mortality. Anti-flu Traditional Chinese Medicine (TCM) has played a significant role in fighting the virus pandemic. In TCM, dandelion is a commonly used ingredient in many therapeutic remedies, either alone or in conjunction with other natural substances. Evidence suggests that dandelion is associated with a variety of pharmacological activities. In this study, we evaluated anti-influenza virus activity of an aqueous extract from dandelion, which was tested for in vitro antiviral activity against influenza virus type A, human A/PR/8/34 and WSN (H1N1)./p pResults/p pResults obstained using antiviral assays, minigenome assay and real-time reverse transcription-PCR analysis showed that 0.625-5 mg/ml of dandelion extracts inhibited infections in Madin-Darby canine kidney (MDCK) cells or Human lung adenocarcinoma cell line (A549) of PR8 or WSN viruses, as well as inhibited polymerase activity and reduced virus nucleoprotein (NP) RNA level. The plant extract did not exhibit any apparent negative effects on cell viability, metabolism or proliferation at the effective dose. This result is consistent with the added advantage of lacking any reported complications of the plants utility in traditional medicine over several centuries./p pConclusion/p pThe antiviral activity of dandelion extracts indicates that a component or components of these extracts possess anti-influenza virus properties. Mechanisms of reduction of viral growth in MDCK or A549 cells by dandelion involve inhibition on virus replication./p
展开
DOI：
10.1186/1743-422X-8-538
被引量：
年份：
2011
Taylor & Francis
Springer
Springer
(全网免费下载)
掌桥科研
Semantic Scholar
(全网免费下载)
查看更多
Semantic Scholar
dx.doi.org
BioMed Central
(全网免费下载)
Europe PMC
NCBI
(全网免费下载)
NCBI
Europe PMC
(全网免费下载)
NCBI
BioMed Central
BioMed Central
(全网免费下载)
OALib
ResearchGate
(全网免费下载)
ProQuest
ResearchGate
EBSCO
Citeseer
(全网免费下载)
EBSCO
学术范
(全网免费下载)
bvsalud.org
casoar.irgrid.ac.cn
学术范
d.scholar.cnki.net
mailer.oalib.net
mysciencework.com
core.ac.uk
paperity.org
biomedsearch.com
search.t.china.driver.research-infrastructures.eu
(全网免费下载)
BioMed Central
(全网免费下载)
mendeley.com
core.kmi.open.ac.uk
core.ac.uk
(全网免费下载)
casoar.irgrid.ac.cn
(全网免费下载)
210.77.64.223
(全网免费下载)
virologyj.com
(全网免费下载)
biomedsearch.com
(全网免费下载)
scienceopen.com
virologyj.com
leaddiscovery.co.uk
Springer
(全网免费下载)
Semantic Scholar
(全网免费下载)
Europe PMC
(全网免费下载)
BioMed Central
(全网免费下载)
BioMed Central
(全网免费下载)
NCBI
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
virologyj.com
(全网免费下载)
casoar.irgrid.ac.cn
(全网免费下载)
biomedsearch.com
(全网免费下载)
core.ac.uk
(全网免费下载)
210.77.64.223
(全网免费下载)
学术范
(全网免费下载)
search.t.china.driver.research-infrastructures.eu
(全网免费下载)
BioMed Central
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
