A convergent synthesis of the macrolide core of migrastatin
摘要：
We describe an efficient synthesis of the 14-membered macrolide core 2 of migrastatin via key intermediate 3 employing a diastereoselective aldol condensation, Lewis acid mediated diastereoselective addition and an exclusive ( Z)-olefination sequence. Yamaguchi esterification of the key intermediate 3 followed by ring-closing metathesis (RCM) produced macrolide 2 with high selectivity and good yield.
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DOI：
10.1016/j.tetlet.2006.06.082
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年份：
2006
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来源期刊
Tetrahedron Letters
2006
引用走势
2007
被引量：9
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