PROCESS FOR PREPARATION OF CLOPIDOGREL, ITS SALTS AND PHARMACEUTICAL COMPOSITIONS
申请(专利)号:
EP20040705140
申请日期:
2004-01-26
公开/公告号:
EP1606231A1
公开/公告日期:
2005-12-21
申请(专利权)人:
NADKARNI, SUNIL SADANAND;PATEL, HASMUKH MATHURBHAI
被引量:
摘要:
The invention discloses an improved process for racemization of methyl (R)(-) alpha-(2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate , a stereoisomer formed in the synthesis of clopidogrel i.e. methyl (S)-(+)-alpha (2-chlorophenyl)-6,7-dihydro-thieno[3,2-c]pyridine-5(4H)-acetate or its salts. The invention is also for an improved process for production of clopidogrel or its pharmaceutically acceptable salts. The invention further discloses novel clopidogrel salts and pharmaceutical compositions comprising them.
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