Ligands for the murine NKG2D receptor: expression by tumor cells and activation of NK cells and macrophages.
摘要：
Natural killer (NK) cells attack tumor and infected cells, but the receptors and ligands that stimulate them are poorly understood. Here we report the expression cloning of two murine ligands for the lectin-like receptor NKG2D. The two ligands, H-60 and Raelβ, are distant relatives of major histocompatibility complex class I molecules. NKG2D ligands are not expressed by most normal cells but are up-regulated on numerous tumor cells. We show that mouse NKG2D is expressed by NK cells, activated CD8~+ T cells and activated macrophages. Expression of either NKG2D ligand by target cells triggers NK cell cytotoxicity and interferon-γ secretion by NK cells, as well as nitric oxide release and tumor necrosis factor α transcription by macrophages. Thus, through their interaction with NKG2D, H-60 and Raelβ are newly identified potent stimulators of innate immunity.
展开
关键词：
Killer Cells, Natural COS Cells CHO Cells Tumor Cells, Cultured Macrophages, Peritoneal Animals Mice, Inbred BALB C Mice, Inbred C57BL Cercopithecus aethiops Humans
DOI：
10.1038/77793
被引量：
年份：
2000
Taylor & Francis
Springer
Nature
Nature
(全网免费下载)
国家科技图书文献中心
(权威机构)
查看更多
EBSCO
Semantic Scholar
万方医学
Semantic Scholar
(全网免费下载)
掌桥科研
dx.doi.org
Oxford Univ Press
NCBI
Europe PMC
ResearchGate
(全网免费下载)
ProQuest
ResearchGate
EBSCO
EBSCO
EBSCO
scienceopen.com
symposium.cshlp.org
www.socolar.com
mendeley.com
vivo.brown.edu
jem.rupress.org
mysciencework.com
pubfacts.com
cghjournal.org
ftp.palgrave-journals.com
cancerimmunolres.aacrjournals.org
embor.embopress.org
frontiersin.org
mcb.berkeley.edu
(全网免费下载)
jacionline.org
学术范
学术范
(全网免费下载)
Nature
(全网免费下载)
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
学术范
(全网免费下载)
mcb.berkeley.edu
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
来源期刊
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
