Process for the O-alkylation of N-(hydroxy) aralkylphenylethanolamines
申请(专利)号:
US19880230860
申请日期:
1988-08-11
公开/公告号:
US4927955A
公开/公告日期:
1990-05-22
申请(专利权)人:
SANOFI
被引量:
摘要:
A process for the preparation of a compound of formula ##STR1## wherein X represents hydrogen, halogen, trifluoromethyl or lower alkyl group; W represents methyl, Q represents hydrogen or W and Q, together, form an ethylene group and R' represents a lower alkyl group which comprises protecting the amino group of the phenol corresponding to the compound of formula I, submitting the compound thus obtained to an alkylation (with a compound of formula Hal--CH.sub.2 --COOR', wherein R' is as defined hereinabove for the formula I and Hal is chlorine, bromine or iodine) and then releasing the amino group of the product thus obtained.
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