Design and synthesis of a potential SH2 domain inhibitor bearing a stereodiversified 1,4-cis-enediol scaffold
摘要：
Synthesis of a potential Src family SH2 domain inhibitor incorporating a 1,4--enediol scaffold is reported. The synthetic route offers straightforward and highly selective access to the enediol and its associated chiral centers. Key steps include stereocontrolled -aldol coupling, amide alkynylation, and asymmetric ketone reduction.Graphical abstract
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DOI：
10.1016/j.tet.2011.10.014
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年份：
2011
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2014
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