Checking on DNA damage in S phase.
摘要：
The precise replication of the genome and the continuous surveillance of its integrity are essential for survival and the avoidance of various diseases. Cells respond to DNA damage by activating a complex network of the so-called checkpoint pathways to delay their cell-cycle progression and repair the defects. In this review we integrate findings on the emerging mechanisms of activation, the signalling pathways and the spatio-temporal organization of the intra-S-phase DNA-damage checkpoint and its impact on the cell-cycle machinery, and discuss its biological significance.
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关键词：
Animals Humans Cell Line Protein Kinases DNA-Binding Proteins Tumor Suppressor Proteins Cell Cycle Proteins Signal Transduction cdc25 Phosphatases S Phase
DOI：
10.1038/nrm1493
被引量：
年份：
2004
Taylor & Francis
Springer
Nature
Nature
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