POULTRY VACCINE, FOR NECROTIC ENTERITIS, COMPRISING A MUTATED CLOSTRIDIUM PERFRINGENS ALPHA TOXIN ANTIGEN, AND METHODS OF PRODUCING THE VACCINE

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申请(专利)号：

EP20070863551

申请日期：

10/26/2007

公开/公告号：

EP2086579

申请(专利权)人：

发明人：

AINLEY, William, Michael，ARMSTRONG, Janna，MADDURI, Krishna，MERLO, Donald, J.，SMITH, Kelley, A.，THOMPSON, Mark, Allen，WEBB, Steven, Robert，SHEN, Liu, Yin

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被引量：

338

摘要：

This invention pertains in part to the development of a vaccine for poultry against necrotic enteritis (NE). The vaccine utilizes a protective antigen that is a mutated, full-length, non-toxic Clostridium perfringens (Cρ) α-toxin protein (Mcpa). Utility of this vaccine was demonstrated by reduction of lesion severity in NE challenge trails, for example. Also disclosed herein are novel approaches for producing this vaccine in significant quantities. One exemplified approach involves producing NE vaccine (mutated alpha toxin) in bacterial expression systems, preferably utilizing the Pseudomonas fluorescens system, for commercial use in controlling NE in the poultry industry. The subject vaccines can be administered preferably to chickens in several different ways. A novel, Type VI alpha toxin from chicken isolates of Cρ is also disclosed.

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