摘要：

The interactions of selective serotonin reuptake inhibitors and tricyclic antidepressants with subtypes of σ receptors were investigated. The rank order of affinity (Ki values) from competition experiments of [3H](+)-pentazocine binding to σ1 sites was: fluvoxamine > sertraline > S(+)-fluoxetine > (±)-fluoxetine > citalopram > imipramine > paroxetine > desipramine > R(−)-fluoxetine > (±)-norfluoxetine. The Ki values of all drugs for σ2 sites were more than 1000 nM. Furthermore, all drugs were more potent at σ1, sites than at σ2 sites. These findings suggest that σ receptors (σ1, site) may play, in some way, a role in the actions of selective serotonin reuptake inhibitors.

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