Genomic analysis of metastasis reveals an essential role for RhoC.
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100
摘要:
Compares the gene expression profile of melanoma variants with low or high metastatic potential by using an in vivo selection scheme to select melanoma cells. Pattern of gene expression that correlates with progression to a metastatic phenotype; Role of the actin-based cytoskeleton, the small GTPase RhoC, which enhances metastasis when overexpressed; Implications for identifying which molecular and cellular events might be important in complex biological processes such as metastasis.
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年份:
2000




















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