摘要：

Enantiomeric excesses of 95-96% are obtained by the asymmetric hydrogenation of α-acylaminoacrylic acids. The olefin configuration, whether E or Z, has a profound influence on the rate and stereospecificity. Excellent selectivity (90% ee) was obtained with an α-enol ester, which is the first outstanding result with a nonamide substrate. A catalyst picture is presented and the stereochemical results are discussed.

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