Thymic major histocompatibility complex antigens and the |[alpha]||[beta]| T-cell receptor determine the CD4/CD8 phenotype of T cells
摘要：
T-cell receptors and T-cell subsets were analysed in T-cell receptor transgenic mice expressing α and β T-cell receptor genes isolated from a male-specific, H–2D b -restricted CD4 –8+ T-cell clone. The results indicate that the specific interaction of the T-cell receptor on immature thymocytes with thymic major histocompatibility complex antigens determines the differentiation of CD4 + 8 + thymocytes into either CD4 + 8 – or CD4 – 8 + mature T cells.
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DOI：
10.1038/335229a0
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年份：
1988
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