The c-myc proto-oncogene regulates cardiac development in transgenic mice.

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作者：

T Jackson，MF Allard，CM Sreenan，LK Doss，JL Swain

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摘要：

During the maturation of the cardiac myocyte, a transition occurs from hyperplastic to hypertrophic growth. The factors that control this transition in the developing heart are unknown. Proto-oncogenes such as have been implicated in the regulation of cellular proliferation and differentiation, and in the heart the switch from myocyte proliferation to terminal differentiation is synchronous with a decrease in abundance. To determine whether can influence myocyte proliferation or differentiation, we examined the in vivo effect of increasing expression during and of preventing the decrease in expression that normally occurs during cardiac . The model system used was a strain of exhibiting constitutive expression of in cardiac myocytes throughout . In these , increased expression was found to be associated with both atrial and ventricular enlargement. This increase in cardiac mass was secondary to myocyte hyperplasia, with the transgenic hearts containing more than twice as many myocytes as did nontransgenic hearts. The results suggest that in the transgenic there is additional hyperplastic growth during fetal . However, this additional proliferative growth is not reflected in abnormal myocyte maturation, as assessed by the expression of the cardiac and skeletal isoforms of . The results of this study indicate that constitutive expression of in the heart during results in enhanced hyperplastic growth and suggest a regulatory role for this proto-oncogene in cardiac .

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关键词：

Biotechnology development gene expression Gene transfer Genetic engineering heart Proto-oncogenes transgenics