摘要：

Am-aza-ing! An efficient and straightforward method for the construction of optically active 9-aminofluorenes by a Lewis acid (LA)-catalyzed asymmetric intramolecular aza-Friedel–Crafts alkylation of N-tert-butanesulfinyl imines has been developed. The reaction can be accomplished with ease in the presence of a catalytic amount of Bi(OTf)3 at room temperature to give the desired products in good yields and up to 96:4 diastereomeric ratio.

展开