摘要：

The weak and short-lasting biological activity of enkephalins can be ascribed to their rapid metabolism. Three types of well defined peptidase activities in CNS may account for the hydrolysis of the opioid pentapeptides : aminopeptidases, angiotensin-converting enzyme and enkephalin-dipeptidylcarboxypeptidase. The properties of these various enzyme activities are described and their possible involvement in the inactivation of synaptically-released enkephalins is discussed in the light of criteria proposed to identify “neuropeptidases”.

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