The TRPM2 channel nexus from oxidative damage to Alzheimer's pathologies: An emerging novel intervention target for age-related dementia
摘要：
Emerging evidence supports an important role for the ROS-sensitive TRPM2 channel in mediating age-related cognitive impairment in Alzheimer's disease (AD), particularly neurotoxicity resulting from generation of excessive neurotoxic Aβ peptides. Here we examined the elusive mechanisms by which Aβ42 activates the TRPM2 channel to induce neurotoxicity in mouse hippocampal neurons. Aβ42-induced...
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关键词：
Oxidative damage Alzheimer’s disease TRPM2 channel Neurodegeneration Neuroinflammation Neurovascular dysfunction
DOI：
10.1016/j.arr.2018.07.002
被引量：
年份：
2018
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