摘要：

Synonyms Fast microcirculation, closed circulation ; Mature forms, trophozoites and schizonts ; Parasitized, infected ; Pitted RBC, once-infected RBC ; RBC, erythrocytes ; Rings, young infected RBC ; Slow microcirculation, open circulation ; Thrombocytopenia, thrombopenia Introduction Splenomegaly is a hallmark of malaria in endemic countries, and splenectomy increases the risk of severe malaria (Fig. 1 ) (Buffet et al. 2011 ). Both observations point to an important role for the spleen in malaria pathogenesis, generally considered as related to its influence on the expression of adhesins on red blood cells (RBC) parasitized by Plasmodium falciparum (David et al. 1983 ; Hommel et al. 1983 ) and to its ability to filter out parasitized RBC (iRBC). This is a logical assumption based on a major function of the spleen: the quality control of circulating RBC (Groom et al. 1991 ), although how the spleen operates this filtration is probably more complex than often thought. In theory, RBC infected with eith ...

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