Local production of B lymphocyte stimulator protein and APRIL in arthritic joints of patients with inflammatory arthritis.
摘要：
BLyS protein and APRIL are locally produced in inflamed joints. Their respective SF levels are differentially regulated, suggesting that they serve different functions. Together, their local production may foster survival and/or expansion of B cells that produce pathogenic autoantibodies and/or promote local T cell activation and consequent joint destruction.
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关键词：
Humans Synovial Fluid Knee Joint Monocytes Neuropeptides Membrane Proteins Antigens, CD14 Nuclear Proteins Flow Cytometry Enzyme-Linked Immunosorbent Assay
DOI：
10.1002/art.10860
被引量：
年份：
2010
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