PI3K and cancer: lessons, challenges and opportunities
摘要：
The central role of phosphoinositide 3-kinase (PI3K) activation in tumour cell biology has prompted a sizeable effort to target PI3K and/or downstream kinases such as AKT and mammalian target of rapamycin (mTOR) in cancer. However, emerging clinical data show limited single-agent activity of inhibitors targeting PI3K, AKT or mTOR at tolerated doses. One exception is the response to PI3K inhibitors in chronic lymphocytic leukaemia, where a combination of cell-intrinsic and -extrinsic activities drive efficacy. Here, we review key challenges and opportunities for the clinical development of inhibitors targeting the PI3K-AKT-mTOR pathway. Through a greater focus on patient selection, increased understanding of immune modulation and strategic application of rational combinations, it should be possible to realize the potential of this promising class of targeted anticancer agents.
展开
关键词：
Heterologous rhamnolipids production Pseudomonas aeruginosa ATCC 9027 Pseudomonas putida KT2440 Transformation Experimental screening design Two-level factorial design
DOI：
10.1038/nrd4204
被引量：
Taylor & Francis
Springer
Nature
Nature
(全网免费下载)
国家科技图书文献中心
(权威机构)
查看更多
万方医学
掌桥科研
Semantic Scholar
dx.doi.org
Ingenta
Cell Press
NCBI
(全网免费下载)
Europe PMC
(全网免费下载)
Europe PMC
NCBI
NCBI
ProQuest
ResearchGate
EBSCO
EBSCO
EBSCO
www.socolar.com
elearning2.uniroma1.it
学术范
cgp.iiarjournals.org
mendeley.com
cshperspectives.cshlp.org
ftp.palgrave-journals.com
onAcademic
escholarship.ucop.edu
mct.aacrjournals.org
jacionline.org
escholarship.org
cghjournal.org
readcube.com
pubfacts.com
学术范
(全网免费下载)
scienceopen.com
embojnl.embopress.org
go.galegroup.com
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
引用走势
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
