The asymmetric synthesis of β-lactam antibiotics - I. application of chiral oxazolidones in the staudinger reaction
摘要:
The reactions of oxazolidone 1 with N-benzylimines proceed with exceptional levels of asymmetric induction to form the cycloadducts 2. Subsequent dissolving metal reduction affords the homochiral β-lactam derivatives 3 in good overall yield (eq 1).
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DOI:
10.1016/S0040-4039(00)89250-3
被引量:
年份:
1985
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