摘要：

A composition comprising nanoparticles having a non-ionic surfactant as a surface modifier adsorbed on the surface thereof and a charged phospholipid as a cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier and methods of making such nanoparticles are described. A preferred non-ionic surfactant is a poloxamine or tyloxapol, and a preferred cloud point modifier is dimyristoyl phosphatidyl glycerol.

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