Targeting RAS signalling pathways in cancer therapy.
摘要：
The RAS proteins control signalling pathways that are key regulators of several aspects of normal cell growth and malignant transformation. They are aberrant in most human tumours due to activating mutations in the RAS genes themselves or to alterations in upstream or downstream signalling components. Rational therapies that target the RAS pathways might inhibit tumour growth, survival and spread. Several of these new therapeutic agents are showing promise in the clinic and many more are being developed.
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关键词：
Animals Humans ras Proteins Antineoplastic Agents GTP Phosphohydrolase Activators Signal Transduction Drug Design Genes, ras Neoplasms
DOI：
10.1038/nrc969
被引量：
年份：
2003
Taylor & Francis
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万方医学
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