Human cdc2 protein kinase is a major cell-cycle regulated tyrosine kinase substrate
摘要：
cdc2 is a catalytic subunit of a protein kinase complex, called the M-phase promoting factor, that induces entry into mitosis and is universal among eukaryotes. In HeLa cells, cdc2 is shown to be the most abundant phosphotyrosine-containing protein and its phosphotyrosine content is subject to cell-cycle regulation. One site ofcdc2 tyrosine phosphorylation in vivo W selectively phosphorylated by pp60 c–src in vitro .
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关键词：
Hela Cells Tyrosine Phosphotyrosine CDC2 Protein Kinase Phosphoproteins Proto-Oncogene Proteins Mitosis Protein-Tyrosine Kinases Cell Cycle Proto-Oncogene Proteins pp60(c-src
DOI：
10.1038/336738a0
被引量：
年份：
1988
Springer
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