Early Stage Diagnosis of Oral Cancer Using 1H NMR–Based Metabolomics
摘要：
Oral cancer is the eighth most common cancer worldwide and represents a significant disease burden. If detected at an early stage, survival from oral cancer is better than 90% at 5 years, whereas late stage disease survival is only 30%. Therefore, there is an obvious clinical utility for novel metabolic markers that help to diagnose oral cancer at an early stage and to monitor treatment response. In the current study, blood samples of oral cancer patients were analyzed using nuclear magnetic resonance spectroscopy to derive a metabolic signature for oral cancer. Using multivariate chemometric analysis, we obtained an excellent discrimination between serum samples from cancer patients and from a control group and could also discriminate between different stages of disease. The metabolic profile obtained for oral cancer is significant, even for early stage disease and relatively small tumors. This suggests a systemic metabolic response to cancer, which bears great potential for early diagnosis.
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关键词：
Humans Neoplasms, Squamous Cell Mouth Neoplasms Tumor Markers, Biological Neoplasm Staging Magnetic Resonance Spectroscopy Aged Middle Aged Female Male
DOI：
10.1593/neo.81396
被引量：
年份：
2009
Elsevier
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万方医学
掌桥科研
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