Macrophages in rheumatoid arthritis
摘要：
The abundance and activation of macrophages in the inflamed synovial membrane/pannus significantly correlates with the severity of rheumatoid arthritis (RA). Although unlikely to be the 'initiators' of RA (if not as antigen-presenting cells in early disease), macrophages possess widespread pro-inflammatory, destructive, and remodeling capabilities that can critically contribute to acute and chronic disease. Also, activation of the monocytic lineage is not locally restricted, but extends to systemic parts of the mononuclear phagocyte system. Thus, selective counteraction of macrophage activation remains an efficacious approach to diminish local and systemic inflammation, as well as to prevent irreversible joint damage.
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关键词：
cytokine fibroblast macrophage monocyte nitric oxide peripheral blood reactive oxygen species rheumatoid arthritis synovial membrane T-cell
DOI：
10.1186/ar86
被引量：
年份：
2000
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