Wild-type ALK and activating ALK-R1275Q and ALK-F1174L mutations upregulate Myc and initiate tumor formation in murine neural crest progenitor cells
摘要：
The anaplastic lymphoma kinase () gene is overexpressed, mutated or amplified in most neuroblastoma (NB), a pediatric neural crest-derived embryonal tumor. The two most frequent mutations, ALK-F1174L and ALK-R1275Q, contribute to NB tumorigenesis in mouse models, and cooperate with MYCN in the oncogenic process. However, the precise role of activating ALK mutations or ALK-wt overexpression in NB tumor initiation needs further clarification.
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关键词：
Neural Crest Animals Humans Mice Neuroblastoma Phosphorylation Mutation Genes, myc Cell Differentiation Up-Regulation
DOI：
10.18632/oncotarget.2036
被引量：
年份：
2014
Semantic Scholar
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万方医学
掌桥科研
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