Acetoacetate, Acetone, and Dibenzylamine (a Contaminant in l‐(+)‐β‐Hydroxybutyrate) Exhibit Direct Anticonvulsant Actions in Vivo
摘要：
Summary: Purpose: To investigate whether ketone bodies are directly anticonvulsant. Methods: We tested the effects of acetoacetate (ACA), acetone, and both stereoisomers, d -()- and l -(+), of β-hydroxybutyrate (BHB) on sensory-evoked seizures in Frings audiogenic seizure-susceptible mice. Results: We found that these ketone bodies, with the exception of the d -()-isomer of BHB, were anticonvulsant in this model. Furthermore, with gas chromatography–mass spectrometry, we confirmed that the activity of l -(+)-BHB was due to dibenzylamine, a chemical contaminant. Conclusions: Our data indicate that the anticonvulsant efficacy of the ketogenic diet may be due in part to the direct actions of ACA and acetone.
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关键词：
Acetoacetic acid Acetoacetate 3‐Hydroxybutyrate β‐Hydroxybutyrate 3‐Hydroxybutanoic acid Acetone Dibenzylamine Ketogenic diet Epilepsy
DOI：
10.1046/j.1528-1157.2002.47901.x
被引量：
年份：
2002
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