Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions
摘要：
Vascular endothelial growth factor (VEGF) stimulates angiogenesis by activating VEGF receptor-2 (VEGFR-2). The role of its homolog, placental growth factor (PlGF), remains unknown. Both VEGF and PlGF bind to VEGF receptor-1 (VEGFR-1), but it is unknown whether VEGFR-1, which exists as a soluble or a membrane-bound type, is an inert decoy or a signaling receptor for PlGF during angiogenesis. Here, we report that embryonic angiogenesis in mice was not affected by deficiency of PlGF (Pgf-/-). VEGF-B, another ligand of VEGFR-1, did not rescue development in Pgf-/- mice. However, loss of PlGF impaired angiogenesis, plasma extravasation and collateral growth during ischemia, inflammation, wound healing and cancer. Transplantation of wild-type bone marrow rescued the impaired angiogenesis and collateral growth in Pgf-/- mice, indicating that PlGF might have contributed to vessel growth in the adult by mobilizing bone-marrow-derived cells. The synergism between PlGF and VEGF was specific, as PlGF deficiency impaired the response to VEGF, but not to bFGF or histamine. VEGFR-1 was activated by PlGF, given that anti-VEGFR-1 antibodies and a Src-kinase inhibitor blocked the endothelial response to PlGF or VEGF/PlGF. By upregulating PlGF and the signaling subtype of VEGFR-1, endothelial cells amplify their responsiveness to VEGF during the 'angiogenic switch' in many pathological disorders.
展开
关键词：
Animals Mice Plasma Neoplasms, Experimental DNA Primers Vascular Endothelial Growth Factor A Pregnancy Proteins Reverse Transcriptase Polymerase Chain Reaction Embryonic and Fetal Development Wound Healing
DOI：
10.1038/87904
被引量：
年份：
2001
Nature
Nature
(全网免费下载)
Springer
国家科技图书文献中心
(权威机构)
EBSCO
查看更多
Semantic Scholar
(全网免费下载)
掌桥科研
万方医学
Semantic Scholar
doi.org
dx.doi.org
BioMed Central
Europe PMC
Oxford Univ Press
NCBI
NCBI
ProQuest
ResearchGate
ResearchGate
(全网免费下载)
EBSCO
Citeseer
(全网免费下载)
EBSCO
EBSCO
ftp.palgrave-journals.com
jasn.asnjournals.org
readcube.com
学术范
hdl.handle.net
ajpheart.physiology.org
openres.ersjournals.com
fertstert.org
orbi.ulg.be
(全网免费下载)
jacionline.org
cghjournal.org
swepub.kb.se
atvb.ahajournals.org
scienceopen.com
mct.aacrjournals.org
wjso.com
orbi.ulg.ac.be
onlinecjc.ca
core.ac.uk
www.socolar.com
internationaljournalofcardiology.com
钛学术
(全网免费下载)
学术范
(全网免费下载)
pubfacts.com
钛学术
orbi.ulg.ac.be
(全网免费下载)
thierryvandendriessche.com
(全网免费下载)
mendeley.com
thierryvandendriessche.com
(全网免费下载)
clinsci.org
orbi.ulg.be
jcs.biologists.org
lirias.kuleuven.be
reproduction-online.org
mayoclinicproceedings.org
ophthalmology.theclinics.com
perspectivesinmedicine.cshlp.org
core.kmi.open.ac.uk
lup.lub.lu.se
ashjournal.com
mysciencework.com
science-open.com
Nature
(全网免费下载)
Semantic Scholar
(全网免费下载)
ResearchGate
(全网免费下载)
Citeseer
(全网免费下载)
orbi.ulg.be
(全网免费下载)
orbi.ulg.ac.be
(全网免费下载)
thierryvandendriessche.com
(全网免费下载)
钛学术
(全网免费下载)
thierryvandendriessche.com
(全网免费下载)
学术范
(全网免费下载)
通过文献互助平台发起求助，成功后即可免费获取论文全文。
相似文献
参考文献
引证文献
辅助模式
引用
文献可以批量引用啦~
欢迎点我试用！
