Blood-pressure and pulse-rate responses to ketamine during general anesthesia
摘要：
It is demonstrated that general anesthetics inhibit the pressor response and positive chronotropic effects of ketamine and imply that the autonomic stimulating properties of ketamine depend upon an intact, nondepressed central nervous system. The administration of ketamine during anesthesia with agents that are sympatholytic, e.g., halothane, uncovers the direct negative inotropic effects of ketamine and can result in significant hypotension. On occasion this hypotension is severe enough (>40 mm Hg) to necessitate the use of a vasopressor. The results of this study suggest that when used as a supplement during general anesthesia, ketamine should be administered with the same caution as any potent anesthetic with myocardial depressant properties.
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DOI：
10.1097/00000542-197312000-00020
被引量：
年份：
1973
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