Identification and functional characterization of brainstem cannabinoid C[B.sub.2] receptors.(Reports)
摘要：
The presence and function of CB2 receptors in central nervous system (CNS) neurons are controversial. We report the expression of CB2 receptor messenger RNA and protein localization on brainstem neurons. These functional CB2 receptors in the brainstem were activated by a CB2 receptor agonist, 2-arachidonoylglycerol, and by elevated endogenous levels of endocannabinoids, which also act at CB1 receptors. CB2 receptors represent an alternative site of action of endocannabinoids that opens the possibility of nonpsychotropic therapeutic interventions using enhanced endocannabinoid levels in localized brain areas.
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关键词：
Animals Ferrets Mice Rats Brain Stem Cerebellum Cerebral Cortex Arachidonic Acids Receptor, Cannabinoid, CB2 Reverse Transcriptase Polymerase Chain Reaction
DOI：
10.1126/science.1115740
被引量：
年份：
2005
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