Mechanisms regulating the concentration and the conformation of progesterone receptor(s) in the uterus
摘要：
After administration of estradiol to castrated guinea pigs, a rise in the uterine concentration of specific progesterone binding sites ("receptor") was observed as early as at 6 hours, and the peak of concentration (8-fold over basal values) was obtained within approximately 24 hours. The effect of the estrogen was prevented by RNA and protein synthesis inhibitors administered 15 min before estrogen. On the other hand, these compounds had no effect when administered 20 hours after estradiol. These results were obtained by using animals with a stable low concentration of receptor (as observed after castration of the cycling guinea pig at diestrus, a time when the concentration is the lowest). From the rate of the decay of binding site concentration during a period of time when no more synthesis of the receptor occurs, the approximate half-life of the receptor was found to be 5 days.
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DOI：
10.1016/j.chembiol.2010.05.017
被引量：
年份：
1973
Wiley
Semantic Scholar
万方医学
Europe PMC
Oxford Univ Press
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